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Our web implementation of T_coffee

Installed T_coffee

We have currently installed version 5.0.3 of the T_coffee.
The reference for this tool is:

T-Coffee: A novel method for multiple sequence alignments. C.Notredame, D. Higgins, J. Heringa,Journal of Molecular Biology,Vol 302, pp205-217,2000


The official T_coffee web page is available at this link.<br />pronostic des cancers par l'analyse bioinformatiq

T_coffee form


T_coffee on the web













  1. Alignment Computation
    • Pairwise Methods : Tcoffee computes its alignments by combining a collection of smaller alignments named a Library. In this section you can select the methods you want to combine into the Tcoffee library. You can choose pairwise and multiple sequence alignment methods
    modality fast Makes a global fasta style pairwise alignment. For proteins, matrix=blosum62mt, gep=-1, gop=-10, ktup=2. For DNA, matrix=idmat (id=10), gep=-1, gop=-20, ktup=5. Each pair of residue is given a score function of the weighting mode defined by -weight.
    slow Slow_pair : Identical to fast_pair, but does a full dynamic programming, using the myers and miller algorithm. This method is recommended if your sequences are distantly related.

    lalign produces local alignments

    clustalw Uses clustalw (default parameters) to align two sequences. Each pair of residue is given a score function of the weighting mode defined by -weight.e

  2. Output
    • You can choose the case and the look of results:
      Case
      upper
      upper case for residues
      lower
      lower case for residues
      Residue Number
      ON
      print residue number
      OFF

      Order
      input
      output order based on sequences input order
      aligned output order based on alignment


      T_coffee Tutorials and Technical Notes

      Please refer, to the T_coffee home page.
      T_coffee Tutorial (HTML) and T_coffee Techmical Notes (HTML)


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